高亲和力锌摄取znuABC系统在鼠伤寒沙门氏菌血清型鼠伤寒毒力中的作用。
Role of the high-affinity zinc uptake znuABC system in Salmonella enterica serovar typhimurium virulence.
作者信息
Campoy Susana, Jara Mónica, Busquets Núria, Pérez De Rozas Ana M, Badiola Ignacio, Barbé Jordi
机构信息
Department of Genetics and Microbiology, Universitat Autònoma de Barcelona, Bellaterra 08193, Spain.
出版信息
Infect Immun. 2002 Aug;70(8):4721-5. doi: 10.1128/IAI.70.8.4721-4725.2002.
Abstract
The Salmonella enterica serovar Typhimurium znuABC genes encoding a high-affinity zinc uptake system and its regulatory zur gene have been cloned. Salmonella serovar Typhimurium zur and znuC knockout mutants have been constructed by marker exchange. The 50% lethal dose of the znuC mutant increased when either orally or intraperitoneally inoculated in BALB/c mice, while virulence of the zur mutant decreased only when mice were intraperitoneally challenged.
摘要
编码高亲和力锌摄取系统的肠炎沙门氏菌鼠伤寒血清型znuABC基因及其调控基因zur已被克隆。通过标记交换构建了鼠伤寒沙门氏菌zur和znuC基因敲除突变体。当将znuC突变体经口或腹腔接种到BALB/c小鼠体内时，其半数致死剂量增加，而只有当小鼠经腹腔攻击时zur突变体的毒力才会降低。
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