幽门螺杆菌在胃癌发生中的作用。

Role of Helicobacter pylori in gastric carcinogenesis.

作者信息

Sepulveda Antonia R, Graham David Y

机构信息

Department of Pathology, PUH-A610, University of Pittsburgh Medical Center, 200 Lothrop St., Pittsburgh, PA 15213-2582, USA.

出版信息

Gastroenterol Clin North Am. 2002 Jun;31(2):517-35, x. doi: 10.1016/s0889-8553(02)00012-2.

DOI:10.1016/s0889-8553(02)00012-2

PMID:12134616

Abstract

Peptic ulcers and gastric malignancies are the two major complication of the course of Helicobacter pylori-associated chronic gastritis. Both gastric adenocarcinomas and MALT lymphomas occur in association with H. pylori infection, and studies support an etiological association. This article discusses the natural history of H. pylori-related gastric carcinogenesis and criteria to identify people susceptible to H. pylori infection-associated gastric cancer. It then reviews the molecular and genetic mechanisms underlying the malignant transformation of the gastric mucosa associated with H. pylori.

摘要

消化性溃疡和胃恶性肿瘤是幽门螺杆菌相关慢性胃炎病程中的两大主要并发症。胃腺癌和黏膜相关淋巴组织淋巴瘤均与幽门螺杆菌感染有关，且研究支持存在病因学关联。本文讨论了幽门螺杆菌相关胃癌发生的自然史以及识别易患幽门螺杆菌感染相关胃癌人群的标准。然后综述了与幽门螺杆菌相关的胃黏膜恶性转化的分子和遗传机制。