Di Bonaventura G, D'Antonio D, Catamo G, D'Ercole S, Piccolomini R
Laboratory of Clinical Microbiology, Department of Biomedical Sciences, G. D'Annunzio University, Chieti, Italy.
Chemotherapy. 2002 Jul;48(3):134-7. doi: 10.1159/000064918.
Novel fluoroquinolones have been recently introduced in the management of neutropenic patients because of their increased activity against gram-positive and gram-negative micro-organisms.
The activities of levofloxacin and ciprofloxacin were determined by the E test against 223 bacterial isolates from patients with haematological malignancies.
In general, the activity of levofloxacin was comparable to that of ciprofloxacin. Levofloxacin was somewhat more active against methicillin-resistant Staphylococcus aureus isolates. All methicillin-susceptible S. aureus isolates were inhibited by ciprofloxacin and levofloxacin at a concentration of < or =0.5 and < or =0.25 microg/ml, respectively. Among gram-negative isolates tested, levofloxacin was significantly (p < 0.001) more active than ciprofloxacin against Stenotrophomonas maltophilia, inhibiting 68 and 53% of these isolates, respectively.
Levofloxacin was not superior to ciprofloxacin in its overall antibacterial activity, although small differences between these agents were seen depending on the species tested. In particular, our data suggested that levofloxacin may potentially be used for the management of S. maltophilia infections in neutropenic patients.
由于新型氟喹诺酮类药物对革兰氏阳性和革兰氏阴性微生物的活性增强，最近已被用于中性粒细胞减少患者的治疗。
采用E试验测定左氧氟沙星和环丙沙星对223株血液系统恶性肿瘤患者分离细菌的活性。
总体而言，左氧氟沙星的活性与环丙沙星相当。左氧氟沙星对耐甲氧西林金黄色葡萄球菌分离株的活性略高。所有对甲氧西林敏感的金黄色葡萄球菌分离株分别在浓度≤0.5和≤0.25μg/ml时被环丙沙星和左氧氟沙星抑制。在测试的革兰氏阴性分离株中，左氧氟沙星对嗜麦芽窄食单胞菌的活性显著高于环丙沙星（p<0.001），分别抑制了68%和53%的此类分离株。
左氧氟沙星的总体抗菌活性并不优于环丙沙星，尽管根据测试的菌种不同，这两种药物之间存在细微差异。特别是，我们的数据表明左氧氟沙星可能可用于中性粒细胞减少患者嗜麦芽窄食单胞菌感染的治疗。
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