Neuroendocrine gene polymorphisms and susceptibility to juvenile idiopathic arthritis.
作者信息
Donn R P, Farhan A, Stevans A, Ramanan A, Ollier W E R, Thomson W
机构信息
Arthritis Research Campaign Epidemiology Unit (ARC/EU), Stopford Building, Oxford Road, Manchester M13 9PT, UK.
出版信息
Rheumatology (Oxford). 2002 Aug;41(8):930-6. doi: 10.1093/rheumatology/41.8.930.
OBJECTIVE
To investigate the involvement of neuroendocrine candidate genes in the aetiopathogenesis of juvenile idiopathic arthritis (JIA).
METHODS
Single-nucleotide polymorphisms and intragenic microsatellite markers within five neuroendocrine candidate genes (CRH, CBG, CYP19, ESR1, PRL) were investigated in 463 clinically characterized UK Caucasian JIA patients and a panel of 276 unrelated, healthy UK Caucasian controls.
RESULTS
None of the polymorphisms investigated showed any statistically significant associations with JIA.
CONCLUSIONS
The lack of association with polymorphisms of these neuroendocrine genes suggests that they are not involved in susceptibility to JIA.
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