ERM蛋白与默林：细胞皮层的整合蛋白

ERM proteins and merlin: integrators at the cell cortex.

作者信息

Bretscher Anthony, Edwards Kevin, Fehon Richard G

机构信息

Department of Molecular Biology and Genetics, Cornell University, Ithaca, New York 14853, USA.

出版信息

Nat Rev Mol Cell Biol. 2002 Aug;3(8):586-99. doi: 10.1038/nrm882.

DOI:10.1038/nrm882

PMID:12154370

Abstract

A fundamental property of many plasma-membrane proteins is their association with the underlying cytoskeleton to determine cell shape, and to participate in adhesion, motility and other plasma-membrane processes, including endocytosis and exocytosis. The ezrin-radixin-moesin (ERM) proteins are crucial components that provide a regulated linkage between membrane proteins and the cortical cytoskeleton, and also participate in signal-transduction pathways. The closely related tumour suppressor merlin shares many properties with ERM proteins, yet also provides a distinct and essential function.

摘要

许多质膜蛋白的一个基本特性是它们与潜在的细胞骨架相关联，以确定细胞形状，并参与黏附、运动及其他质膜过程，包括内吞作用和外排作用。埃兹蛋白-根蛋白-膜突蛋白（ERM）是关键组分，它们在膜蛋白与皮质细胞骨架之间提供一种受调控的连接，并且也参与信号转导通路。密切相关的肿瘤抑制因子默林与ERM蛋白有许多共同特性，但也具有独特且重要的功能。