雌激素受体1基因多态性与帕金森病痴呆之间无关联。
Lack of association between an estrogen receptor 1 gene polymorphism and Parkinson's disease with dementia.
作者信息
Mattila K M, Rinne J O, Röyttä M, Laippala P, Lehtimäki T
机构信息
Department of Clinical Chemistry, Centre for Laboratory Medicine, Tampere University Hospital, Finland.
出版信息
Acta Neurol Scand. 2002 Sep;106(3):128-30. doi: 10.1034/j.1600-0404.2002.01331.x.
OBJECTIVE
To test for an association between an estrogen receptor 1 (ESR1) gene polymorphism and Parkinson's disease with dementia (PDD) in Finnish subjects.
SUBJECTS AND METHODS
Forty-one clinically demented and pathologically confirmed PDD patients and 59 cognitively intact aged individuals with normal neuropathology were genotyped for the ESR1 PvuII polymorphism.
RESULTS
We found no significant differences in the genotype or allele frequencies when the PDD patients were compared with the controls. Nor were there any significant differences in these frequencies when the PDD patients with coexisting Alzheimer's disease pathology were compared with the control group.
CONCLUSION
We failed to demonstrate an association between dementia-associated PD and the ESR1 PvuII polymorphism in Finnish subjects.
目的
检测芬兰人群中雌激素受体1（ESR1）基因多态性与帕金森病痴呆（PDD）之间的关联。
受试者与方法
对41例临床诊断为痴呆且经病理证实的PDD患者以及59例认知功能正常且神经病理学正常的老年个体进行ESR1 PvuII基因多态性基因分型。
结果
将PDD患者与对照组进行比较时，我们发现基因型或等位基因频率无显著差异。将合并阿尔茨海默病病理改变的PDD患者与对照组进行比较时，这些频率也无显著差异。
结论
我们未能证实芬兰人群中与痴呆相关的帕金森病与ESR1 PvuII基因多态性之间存在关联。
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