Syntheses of polycationic dendrimers on lipophilic peptide core for complexation and transport of oligonucleotides.
作者信息
Wimmer Norbert, Marano Robert J, Kearns Philip S, Rakoczy Elizabeth P, Toth Istvan
机构信息
School of Pharmacy, The University of Queensland, Steele Building, St. Lucia, Qld 4072, Australia.
出版信息
Bioorg Med Chem Lett. 2002 Sep 16;12(18):2635-7. doi: 10.1016/s0960-894x(02)00511-5.
Abstract
Synthesis of novel polycationic lipophilic peptide core(s) was accomplished and these agents successfully transfected human retinal pigment epithelium cells with ODN1 upon complexation with the oligonucleotide. The level of transfection was indirectly measured by the decreased production of the protein hVEGF (human vascular endothelial growth factor) in comparison to the transfection agent cytofectin GSV.
摘要
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