Keller A, Terrier F, Schneider P-A, Bianchi S, Howarth N, De Moerloose P
Department of Radiology, Univesity Hospitals Geneva, Switzerland.
Skeletal Radiol. 2002 Sep;31(9):550-3. doi: 10.1007/s00256-002-0518-8. Epub 2002 May 25.
Haemophilic pseudotumour (HP) is a rare but very serious complication of haemophilia. HP affects mainly patients with severe haemophilia and those who have developed antibodies to factor VIII or factor IX. We report on a 45-year-old man with haemophilia A and high titres of inhibitors who developed an extensive HP with progressive destruction of the right ilium over a period of 12 years. The different therapeutic options (conservative management by replacement therapy, surgical approach, radiotherapy, percutaneous evacuation with secondary refilled cavity and transcatheter arterial embolization) are reviewed.
血友病性假肿瘤(HP)是血友病一种罕见但非常严重的并发症。HP主要影响重度血友病患者以及那些已产生针对凝血因子VIII或凝血因子IX抗体的患者。我们报告了一名45岁的甲型血友病男性患者,其体内存在高滴度的抑制物,在12年的时间里发生了广泛的HP,并导致右髂骨逐渐遭到破坏。本文对不同的治疗选择(通过替代疗法进行保守治疗、手术方法、放射治疗、经皮穿刺抽液并二次填充空腔以及经导管动脉栓塞术)进行了综述。