银杏叶提取物对不同大鼠脑区β-肾上腺素能受体的影响。

Effect of Ginkgo biloba extract on beta-adrenergic receptors in different rat brain regions.

作者信息

Hadjiivanova Ch I, Petkov V V

机构信息

Department of Chemistry and Biochemistry, Faculty of Ecology, University of Forestry, 10 Kliment Ohridski Avenue, Sofia 1756, Bulgaria.

出版信息

Phytother Res. 2002 Aug;16(5):488-90. doi: 10.1002/ptr.933.

DOI:10.1002/ptr.933

PMID:12203273

Abstract

The effect of oral administration of Ginkgo biloba extract at a dose of 90 mg/kg for 7 consecutive days on rat brain beta-adrenergic receptors in the frontal cortex, hippocampus, striatum and hypothalamus was studied. Ginkgo biloba treatment induced a significant decrease in the density (B(max)) of beta-adrenoreceptors in the frontal cortex and hippocampus. It has been suggested that modulation of the beta-adrenergic system is implicated in the favourable effects of Ginkgo biloba extracts on learning and memory.

摘要

研究了连续7天口服90mg/kg剂量的银杏叶提取物对大鼠额叶皮质、海马体、纹状体和下丘脑β-肾上腺素能受体的影响。银杏叶治疗导致额叶皮质和海马体中β-肾上腺素能受体的密度（B(max)）显著降低。有人提出，β-肾上腺素能系统的调节与银杏叶提取物对学习和记忆的有益作用有关。