电压门控钾通道及其相关蛋白

The voltage-gated potassium channels and their relatives.

作者信息

Yellen Gary

机构信息

Department of Neurobiology, Harvard Medical School, 220 Longwood Avenue, Boston, Massachusetts 02115, USA.

出版信息

Nature. 2002 Sep 5;419(6902):35-42. doi: 10.1038/nature00978.

DOI:10.1038/nature00978

PMID:12214225

Abstract

The voltage-gated potassium channels are the prototypical members of a family of membrane signalling proteins. These protein-based machines have pores that pass millions of ions per second across the membrane with astonishing selectivity, and their gates snap open and shut in milliseconds as they sense changes in voltage or ligand concentration. The architectural modules and functional components of these sophisticated signalling molecules are becoming clear, but some important links remain to be elucidated.

摘要

电压门控钾通道是膜信号蛋白家族的典型成员。这些基于蛋白质的机器具有孔道，能够以惊人的选择性每秒使数百万个离子穿过膜，并且它们的门会在感知电压或配体浓度变化时在几毫秒内迅速打开和关闭。这些复杂信号分子的结构模块和功能组件正逐渐明晰，但一些重要的联系仍有待阐明。