巨细胞病毒编码的MHC I类同源物的功能。

Function of CMV-encoded MHC class I homologues.

作者信息

Farrell H E, Davis-Poynter N J, Andrews D M, Degli-Esposti M A

机构信息

Animal Health Trust, Virology Section, Kentford, Newmarket, Suffolk CB8 7UU, UK.

出版信息

Curr Top Microbiol Immunol. 2002;269:131-51. doi: 10.1007/978-3-642-59421-2_9.

DOI:10.1007/978-3-642-59421-2_9

PMID:12224506

Abstract

Homologues of MHC class I proteins have been identified in the genomes of human, murine and rat cytomegaloviruses (CMVs). Given the pivotal role of the MHC class I protein in cellular immunity, it has been postulated that the viral homologues subvert the normal antiviral immune response of the host, thus promoting virus replication and dissemination in an otherwise hostile environment. This review focuses on recent studies of the CMV MHC class I homologues at the molecular, cellular and whole animal level and presents current hypotheses for their roles in the CMV life cycle.

摘要

在人类、小鼠和大鼠巨细胞病毒（CMV）的基因组中已鉴定出MHC I类蛋白的同源物。鉴于MHC I类蛋白在细胞免疫中起关键作用，据推测病毒同源物会破坏宿主正常的抗病毒免疫反应，从而在原本不利的环境中促进病毒复制和传播。本综述重点关注巨细胞病毒MHC I类同源物在分子、细胞和整体动物水平的最新研究，并提出了它们在巨细胞病毒生命周期中作用的当前假说。