Moon Jeong Bin, Kim Ju Cheol, Yoon Bo Hyun, Romero Roberto, Kim Gilja, Oh Soo-Young, Kim Miha, Shim Soon-Sup
Department of Obstetrics and Gynecology, Seoul National University College of Medicine, Laboratory of Fetal Medicine Research, Clinical Research Institute, Seoul National University Hospital, Seoul, Korea.
J Perinat Med. 2002;30(4):301-6. doi: 10.1515/JPM.2002.044.
To examine if increased concentrations of matrix metalloproteinase-8 (MMP-8) in amniotic fluid are associated with the development of cerebral palsy at the age of three years.
The relationship between amniotic fluid concentrations of MMP-8 and the development of cerebral palsy was examined in 116 preterm singleton newborns (gestational age at birth < 35 weeks) born to mothers who underwent amniocentesis and were followed for at least 3 years. Amniotic fluid was cultured for aerobic and anaerobic bacteria and mycoplasmas. MMP-8 concentrations were measured by specific immunoassays. Cerebral palsy was diagnosed by neuro developmental assessment at the age of three years.
Median amniotic fluid concentration of MMP-8 was significantly higher in mothers whose newborns developed cerebral palsy than in mothers whose newborns did not develop cerebral palsy (median 153.9 [range < 0.3-1535.9] ng/ml vs median 6.4 [range < 0.3-3836.8] ng/ml; p < 0.01). Neonates who developed cerebral palsy were delivered at earlier gestational age than those without cerebral palsy. After adjustment for the gestational age at birth and the results of amniotic fluid culture, elevated concentrations of amniotic fluid MMP-8 significantly increased the odds of development of cerebral palsy (odds ratio, 6.0; 95% confidence interval, 1.1-33.0; p < 0.05).
Increased concentrations of amniotic fluid MMP-8 are associated with the subsequent development of cerebral palsy at the age of 3 years.
研究羊水基质金属蛋白酶-8（MMP-8）浓度升高是否与三岁时脑瘫的发生有关。
对116例接受羊膜穿刺术的单胎早产新生儿（出生孕周<35周）进行研究，随访至少3年，检测羊水MMP-8浓度与脑瘫发生之间的关系。羊水进行需氧菌、厌氧菌和支原体培养。通过特异性免疫测定法测量MMP-8浓度。三岁时通过神经发育评估诊断脑瘫。
新生儿发生脑瘫的母亲羊水MMP-8中位数浓度显著高于新生儿未发生脑瘫的母亲（中位数153.9[范围<0.3-1535.9]ng/ml对中位数6.4[范围<0.3-3836.8]ng/ml；p<0.01）。发生脑瘫的新生儿出生孕周比未发生脑瘫的新生儿早。在调整出生孕周和羊水培养结果后，羊水MMP-8浓度升高显著增加了脑瘫发生的几率（优势比，6.0；95%置信区间，1.1-33.0；p<0.05）。
羊水MMP-8浓度升高与三岁时随后发生的脑瘫有关。
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