适应高海拔低氧环境的大鼠的脱适应过程。

De-acclimatization process of rats acclimatized to high altitude hypoxia.

作者信息

Yamamoto C, Mori S, Murata Y, Seo H, Nakatsuka M, Yoshino M

机构信息

Department of Endocrinology and Metabolism, Division of Molecular and Cellular Adaptation, Research Institute of Environmental Medicine, Nagoya University, Nagoya, Japan.

出版信息

Environ Med. 1993;37(1):31-4.

PMID:12269349

Abstract

The de-acclimatization process in rats acclimatized to high altitude hypoxia was analyzed according to the changes in the activities of hepatic enzymes. The activities of tryptophan 2,3-dioxygenase and tyrosine aminotransferase in the liver of non-acclimatized rats were increased, whereas those of acclimatized rats were decreased after exposure to a simulated altitude of 8,000 m. When the acclimatized rats were kept under normoxic conditions for 8 days and over, the suppression of enzyme induction was nullified, and both enzymes were induced by exposure to the simulated 8,000 m altitude. De-acclimatization of rats acclimatized to hypoxia can be completed in 8-11 days.

摘要

根据肝酶活性的变化，分析了适应高海拔低氧环境的大鼠的脱适应过程。未适应的大鼠肝脏中色氨酸2,3-双加氧酶和酪氨酸转氨酶的活性增加，而适应的大鼠在暴露于模拟海拔8000米后这些酶的活性降低。当适应的大鼠在常氧条件下饲养8天及以上时，酶诱导的抑制作用消失，两种酶在暴露于模拟8000米海拔时均被诱导。适应低氧环境的大鼠的脱适应可在8-11天内完成。