肿瘤坏死因子-α在正常妊娠期间胰岛素抵抗中的作用。

Role of tumour necrosis factor-alpha in insulin resistance during normal pregnancy.

作者信息

Melczer Zs, Bánhidy F, Csömör S, Kovács M, Siklós P, Winkler G, Cseh K

机构信息

Second Department of Obstetrics and Gynaecology, Semmelweis University Faculty of Medicine, Ulloi út 78/a, H-1082, Budapest, Hungary.

出版信息

Eur J Obstet Gynecol Reprod Biol. 2002 Oct 10;105(1):7-10. doi: 10.1016/s0301-2115(02)00108-2.

DOI:10.1016/s0301-2115(02)00108-2

PMID:12270556

Abstract

OBJECTIVE

Role of tumour necrosis factor-alpha (TNF-alpha) was studied in insulin resistance during pregnancy.

STUDY DESIGN

Serum TNF-alpha (ELISA) and fasting C-peptide (Cp) (RIA) concentrations were measured in 40 healthy pregnant women (15, 12 and 13 of them in the 1st, 2nd and 3rd trimesters, respectively) and in 25 healthy non-pregnant women in a case-control study.

RESULTS

TNF-alpha (X+/-S.D.: 5.33+/-0.46 pg/ml) and Cp levels (3.37+/-1.30 ng/ml) were significantly higher in the 3rd trimester as compared with matched healthy controls (TNF: 4.07+/-0.26, Cp: 1.05+/-0.36) and to the pregnant women in 1st (TNF: 4.04+/-0.26, Cp: 1.34+/-0.59) and 2nd (TNF: 4.35+/-0.32, Cp: 1.11+/-0.35) trimesters. Significant positive linear correlation was calculated among TNF-alpha, Cp, Cp/blood glucose ratio (indirect parameters of insulin resistance) and body mass indexes (BMIs) of pregnant women (P<0.01).

CONCLUSION

TNF-alpha may contribute to the insulin resistance during the course of normal pregnancy.

摘要

目的

研究肿瘤坏死因子-α（TNF-α）在孕期胰岛素抵抗中的作用。

研究设计

在一项病例对照研究中，对40名健康孕妇（分别为15名、12名和13名处于孕早期、孕中期和孕晚期）及25名健康非孕女性测定血清TNF-α（酶联免疫吸附测定法）和空腹C肽（Cp）（放射免疫分析法）浓度。

结果

与匹配的健康对照组（TNF：4.07±0.26，Cp：1.05±0.36）以及孕早期（TNF：4.04±0.26，Cp：1.34±0.59）和孕中期（TNF：4.35±0.32，Cp：1.11±0.35）的孕妇相比，孕晚期的TNF-α（X±标准差：5.33±0.46 pg/ml）和Cp水平（3.37±1.30 ng/ml）显著更高。孕妇的TNF-α、Cp、Cp/血糖比值（胰岛素抵抗的间接参数）和体重指数（BMI）之间计算出显著的正线性相关性（P<0.01）。