使用长效注射避孕法的女性的一些代谢和激素变化。

Some metabolic and hormonal changes in women using long acting injectable contraceptives.

作者信息

Abdel-sayed W S, Toppozada H K, Said S A, El-sayed O K

出版信息

Alex J Pharm Sci. 1989 Mar;3(1):29-32.

Abstract

Some metabolic and hormonal changes in women using longacting injectables as a contraceptive method were examined. The 2 main injectables utilized were depomedroxyprogesterone acetate (DMPA), given every 90 +or- 5 days, and norethisterone enanthate (NET/EN) injected every 60 +or- 5 days. None of the studied cases became pregnant during injectable use, indicating the high contraceptive efficacy of the method. No statistically significant changes were observed in hemoglobin, hematocrit, all protein fractions including albumin, alpha1, alpha2 beta, gamma immunoglobulins IgG, IgA, and IgM after 6 and 12 months in both groups of injectable users as compared with the preinjection values. Statistically significant suppression of the estimated hormones, Follitropin, Luteotropin, and Estradiol-17beta were detected in both groups of NET/EN and DMPA users, after 6 and 12 months, as compared with the preinjection values.

摘要

研究了使用长效注射剂作为避孕方法的女性的一些代谢和激素变化。所使用的两种主要注射剂为醋酸甲羟孕酮（DMPA），每90±5天注射一次，以及庚酸炔诺酮（NET/EN），每60±5天注射一次。在使用注射剂期间，所有研究病例均未怀孕，表明该方法具有较高的避孕效果。与注射前值相比，两组注射剂使用者在6个月和12个月后，血红蛋白、血细胞比容、包括白蛋白、α1、α2、β、γ免疫球蛋白IgG、IgA和IgM在内的所有蛋白质组分均未观察到统计学上的显著变化。与注射前值相比，NET/EN组和DMPA组使用者在6个月和12个月后，促卵泡激素、促黄体激素和雌二醇-17β等估计激素均有统计学上的显著抑制。