4-羟基丁基-丁基亚硝胺对叙利亚仓鼠的致癌性。
Carcinogenicity of 4-hydroxybutyl-butylnitrosamine in Syrian hamsters.
作者信息
Althoff J, Krüger F W
出版信息
Cancer Lett. 1975 Sep;1(1):15-9. doi: 10.1016/s0304-3835(75)94625-x.
PMID:1235053
Abstract
4-Hydroxybutyl-butylnitrosamine (HBBN), a urinary metabolite of dibutylnitrosamine (DBN) was shown to induce respiratory and bile duct tumors as well as carcinomas of the urinary bladder in Syrian golden hamsters. This contrasts with results previously obtained in rats and demonstrates that HBBN is not a specific bladder carcinogen. Bronchogenic tumors, seen in DBN-treated hamsters, were not observed after injection of HBBN.
摘要
4-羟基丁基-丁基亚硝胺（HBBN）是二丁基亚硝胺（DBN）的一种尿液代谢产物，已证明它可在叙利亚金仓鼠中诱发呼吸道和胆管肿瘤以及膀胱癌。这与之前在大鼠中获得的结果形成对比，表明HBBN不是一种特异性的膀胱致癌物。在注射HBBN后未观察到在接受DBN处理的仓鼠中出现的支气管源性肿瘤。
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