免疫系统中的核因子-κB调控

NF-kappaB regulation in the immune system.

作者信息

Li Qiutang, Verma Inder M

机构信息

The Salk Institute, Laboratory of Genetics, 10010 North Torrey Pines Road, La Jolla, California 92037, USA.

出版信息

Nat Rev Immunol. 2002 Oct;2(10):725-34. doi: 10.1038/nri910.

DOI:10.1038/nri910

PMID:12360211

Abstract

The nuclear factor-kappaB (NF-kappaB)/REL family of transcription factors has a central role in coordinating the expression of a wide variety of genes that control immune responses. There has been intense scientific activity in the NF-kappaB field owing to the involvement of these factors in the activation and regulation of key molecules that are associated with diseases ranging from inflammation to cancer. In this review, we focus on our current understanding of NF-kappaB regulation and its role in the immune system and inflammatory diseases. We also discuss the role of NF-kappaB proteins as potential therapeutic targets in clinical applications.

摘要

核因子-κB（NF-κB）/REL转录因子家族在协调多种控制免疫反应的基因表达中起着核心作用。由于这些因子参与了从炎症到癌症等多种疾病相关关键分子的激活和调节，NF-κB领域一直有大量的科学研究活动。在这篇综述中，我们重点阐述了目前对NF-κB调节及其在免疫系统和炎症性疾病中作用的理解。我们还讨论了NF-κB蛋白作为临床应用中潜在治疗靶点的作用。