从桃欧文氏菌中鉴定出一种染色体携带的超广谱A类β-内酰胺酶。
Identification of a chromosome-borne expanded-spectrum class a beta-lactamase from Erwinia persicina.
作者信息
Vimont Sophie, Poirel Laurent, Naas Thierry, Nordmann Patrice
机构信息
Service de Bactériologie-Virologie, Hôpital de Bicêtre, Assistance Publique/Hôpitaux de Paris, Faculté de Médecine Paris-Sud, 94275 Le Kremlin-Bicêtre, France.
出版信息
Antimicrob Agents Chemother. 2002 Nov;46(11):3401-5. doi: 10.1128/AAC.46.11.3401-3405.2002.
Abstract
From whole-cell DNA of an enterobacterial Erwinia persicina reference strain that displayed a penicillinase-related antibiotic-resistant phenotype, a beta-lactamase gene was cloned and expressed in Escherichia coli. It encoded a clavulanic-acid-inhibited Ambler class A beta-lactamase, ERP-1, with a pI value of 8.1 and a relative molecular mass of ca. 28 kDa. ERP-1 shared 45 to 50% amino acid identity with the most closely related enzymes, the chromosomally encoded enzymes from Citrobacter koseri, Kluyvera ascorbata, Kluyvera cryocrescens, Klebsiella oxytoca, Proteus vulgaris, Proteus penneri, Rahnella aquatilis, Serratia fonticola, Yersinia enterocolitica, and the plasmid-mediated enzymes CTX-M-8 and CTX-M-9. The substrate profile of the noninducible ERP-1 was similar to that of these beta-lactamases. ERP-1 is the first extended-spectrum beta-lactamase from an enterobacterial species that is plant associated and plant pathogenic.
摘要
从一株表现出青霉素酶相关抗生素耐药表型的肠杆菌欧文氏菌参考菌株的全细胞DNA中，克隆了一个β-内酰胺酶基因并在大肠杆菌中表达。它编码一种克拉维酸抑制的安布勒A类β-内酰胺酶ERP-1，其pI值为8.1，相对分子质量约为28 kDa。ERP-1与关系最密切的酶，即来自科氏柠檬酸杆菌、抗坏血酸克吕沃尔菌、低温克吕沃尔菌、产酸克雷伯菌、普通变形杆菌、彭氏变形杆菌、水生拉恩菌、弗氏沙雷菌、小肠结肠炎耶尔森菌的染色体编码酶，以及质粒介导的酶CTX-M-8和CTX-M-9，氨基酸同一性为45%至50%。不可诱导的ERP-1的底物谱与这些β-内酰胺酶相似。ERP-1是来自与植物相关且具有植物致病性的肠杆菌物种的首个超广谱β-内酰胺酶。
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