人类巨细胞病毒US10基因产物会延迟主要组织相容性复合体I类分子的转运。
The human cytomegalovirus US10 gene product delays trafficking of major histocompatibility complex class I molecules.
作者信息
Furman Margo H, Dey Neelendu, Tortorella Domenico, Ploegh Hidde L
机构信息
Department of Pathology, Harvard Medical School, Boston, Massachusetts 02115, USA.
出版信息
J Virol. 2002 Nov;76(22):11753-6. doi: 10.1128/jvi.76.22.11753-11756.2002.
Abstract
Human cytomegalovirus (HCMV) US10 encodes a glycoprotein that binds to major histocompatibility complex (MHC) class I heavy chains. While expression of US10 delays the normal trafficking of MHC class I molecules out of the endoplasmic reticulum, US10 does not obviously facilitate or inhibit the action of two other HCMV-encoded MHC class I binding proteins, US2 and US11.
摘要
人类巨细胞病毒（HCMV）的US10编码一种与主要组织相容性复合体（MHC）I类重链结合的糖蛋白。虽然US10的表达会延迟MHC I类分子从内质网的正常转运，但US10并不会明显促进或抑制另外两种HCMV编码的MHC I类结合蛋白US2和US11的作用。
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本文引用的文献
1
Human cytomegalovirus US7, US8, US9, and US10 are cytoplasmic glycoproteins, not found at cell surfaces, and US9 does not mediate cell-to-cell spread.
J Virol. 2002 Jun;76(11):5748-58. doi: 10.1128/jvi.76.11.5748-5758.2002.
2
Human cytomegalovirus gene products US2 and US11 differ in their ability to attack major histocompatibility class I heavy chains in dendritic cells.
J Virol. 2002 May;76(10):5043-50. doi: 10.1128/jvi.76.10.5043-5050.2002.
3
Membrane-specific, host-derived factors are required for US2- and US11-mediated degradation of major histocompatibility complex class I molecules.
J Biol Chem. 2002 Feb 1;277(5):3258-67. doi: 10.1074/jbc.M109765200. Epub 2001 Nov 20.
4
Antigen presentation subverted: Structure of the human cytomegalovirus protein US2 bound to the class I molecule HLA-A2.
Proc Natl Acad Sci U S A. 2001 Jun 5;98(12):6794-9. doi: 10.1073/pnas.121172898.
5
Signal peptide cleavage of a type I membrane protein, HCMV US11, is dependent on its membrane anchor.
EMBO J. 2001 Apr 2;20(7):1573-82. doi: 10.1093/emboj/20.7.1573.
6
Human cytomegalovirus immediate early glycoprotein US3 retains MHC class I molecules by transient association.
Traffic. 2000 Apr;1(4):318-25. doi: 10.1034/j.1600-0854.2000.010405.x.
7
Structural and functional dissection of human cytomegalovirus US3 in binding major histocompatibility complex class I molecules.
J Virol. 2000 Dec;74(23):11262-9. doi: 10.1128/jvi.74.23.11262-11269.2000.
8
Viral subversion of the immune system.
Annu Rev Immunol. 2000;18:861-926. doi: 10.1146/annurev.immunol.18.1.861.
9
Trophoblast class I major histocompatibility complex (MHC) products are resistant to rapid degradation imposed by the human cytomegalovirus (HCMV) gene products US2 and US11.
J Exp Med. 1998 Aug 3;188(3):497-503. doi: 10.1084/jem.188.3.497.
10
Natural killer cell receptors.
Curr Opin Immunol. 1998 Jun;10(3):298-305. doi: 10.1016/s0952-7915(98)80168-4.
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