Abramsky O, Aharonov A, Webb C, Fuchs S
Clin Exp Immunol. 1975 Jan;19(1):11-6.
Lymphocytes from patients with myasthenia gravis were stimulated when cultured in vitro with an electric eel extract enriched in acetylcholine receptor. No stimulation was observed with other antigens from nerve or muscle origin. Lymphocytes from non-myasthenic patients showed no response to any of these antigens. These findings suggest that an in vivo sensitization of lymphocytes to self acetylcholine receptor may occur in myasthenia gravis. The presence of sensitized lymphocytes, probably resulting from an autoimmune mechanism, might be an important factor in the pathogenesis of the neuromuscular block in this disease.
重症肌无力患者的淋巴细胞在体外与富含乙酰胆碱受体的电鳗提取物一起培养时会受到刺激。而来自神经或肌肉来源的其他抗原则未观察到刺激作用。非重症肌无力患者的淋巴细胞对这些抗原均无反应。这些发现提示,重症肌无力患者体内可能发生淋巴细胞对自身乙酰胆碱受体的致敏。致敏淋巴细胞的存在,可能源于自身免疫机制,可能是该疾病神经肌肉阻滞发病机制中的一个重要因素。