Suppr超能文献

贝克斯(Bex)是必需的大肠杆菌GTP酶埃拉(Era)在枯草芽孢杆菌中的同源物,是正常细胞分裂和孢子形成所必需的。

Bex, the Bacillus subtilis homolog of the essential Escherichia coli GTPase Era, is required for normal cell division and spore formation.

作者信息

Minkovsky Natalie, Zarimani Arash, Chary Vasant K, Johnstone Brian H, Powell Bradford S, Torrance Pamela D, Court Donald L, Simons Robert W, Piggot Patrick J

机构信息

Department of Microbiology and Immunology, Temple University School of Medicine, Philadelphia, Pennsylvania 19140, USA.

出版信息

J Bacteriol. 2002 Nov;184(22):6389-94. doi: 10.1128/JB.184.22.6389-6394.2002.

Abstract

The Bacillus subtilis bex gene complemented the defect in an Escherichia coli era mutant. The Bex protein showed 39 percent identity and 67 percent similarity to the E. coli Era GTPase. In contrast to era, bex was not essential in all strains. bex mutant cells were elongated and filled with diffuse nucleoid material. They grew slowly and exhibited severely impaired spore formation.

摘要

枯草芽孢杆菌的bex基因弥补了大肠杆菌era突变体的缺陷。Bex蛋白与大肠杆菌Era GTP酶有39%的同一性和67%的相似性。与era不同,bex在所有菌株中并非必需。bex突变体细胞拉长,充满弥散的类核物质。它们生长缓慢,孢子形成严重受损。

相似文献

2
Mutational analysis of Era, an essential GTP-binding protein of Escherichia coli.
FEMS Microbiol Lett. 1996 Feb 1;136(1):57-62. doi: 10.1111/j.1574-6968.1996.tb08025.x.
6
Purification, characterization and crystallization of ERA, an essential GTPase from Escherichia coli.
FEBS Lett. 1999 Feb 26;445(2-3):425-30. doi: 10.1016/s0014-5793(99)00178-7.
8
Cell cycle arrest in Era GTPase mutants: a potential growth rate-regulated checkpoint in Escherichia coli.
Mol Microbiol. 1998 Feb;27(4):739-50. doi: 10.1046/j.1365-2958.1998.00719.x.
10
The GTPase, CpgA(YloQ), a putative translation factor, is implicated in morphogenesis in Bacillus subtilis.
Mol Genet Genomics. 2006 Apr;275(4):409-20. doi: 10.1007/s00438-006-0097-9. Epub 2006 Feb 17.

引用本文的文献

1
DNA aptamer Apt 2 targets ERA from Staphylococcus aureus and limits GTP hydrolysis.
Sci Rep. 2025 Aug 22;15(1):30879. doi: 10.1038/s41598-025-15180-9.
2
Nucleic acid-binding KH domain proteins influence a spectrum of biological pathways including as part of membrane-localized complexes.
J Struct Biol X. 2024 Jun 27;10:100106. doi: 10.1016/j.yjsbx.2024.100106. eCollection 2024 Dec.
3
GTPase Era at the heart of ribosome assembly.
Front Mol Biosci. 2023 Oct 4;10:1263433. doi: 10.3389/fmolb.2023.1263433. eCollection 2023.
4
The (p)ppGpp-binding GTPase Era promotes rRNA processing and cold adaptation in Staphylococcus aureus.
PLoS Genet. 2019 Aug 29;15(8):e1008346. doi: 10.1371/journal.pgen.1008346. eCollection 2019 Aug.
5
Role of Era in assembly and homeostasis of the ribosomal small subunit.
Nucleic Acids Res. 2019 Sep 5;47(15):8301-8317. doi: 10.1093/nar/gkz571.
6
HflX protein protects from manganese stress.
J Biosci. 2018 Dec;43(5):1001-1013.
9
The universally conserved prokaryotic GTPases.
Microbiol Mol Biol Rev. 2011 Sep;75(3):507-42, second and third pages of table of contents. doi: 10.1128/MMBR.00009-11.
10
YsxC, an essential protein in Staphylococcus aureus crucial for ribosome assembly/stability.
BMC Microbiol. 2009 Dec 18;9:266. doi: 10.1186/1471-2180-9-266.

本文引用的文献

1
YsxC, a putative GTP-binding protein essential for growth of Bacillus subtilis 168.
J Bacteriol. 2000 Dec;182(23):6819-23. doi: 10.1128/JB.182.23.6819-6823.2000.
2
Analysis of guanine nucleotide binding and exchange kinetics of the Escherichia coli GTPase Era.
J Bacteriol. 2000 Jun;182(12):3460-6. doi: 10.1128/JB.182.12.3460-3466.2000.
3
Era GTPase of Escherichia coli: binding to 16S rRNA and modulation of GTPase activity by RNA and carbohydrates.
Microbiology (Reading). 2000 May;146 ( Pt 5):1071-1083. doi: 10.1099/00221287-146-5-1071.
4
Penicillin-binding protein-related factor A is required for proper chromosome segregation in Bacillus subtilis.
J Bacteriol. 2000 Mar;182(6):1650-8. doi: 10.1128/JB.182.6.1650-1658.2000.
5
Era, an essential Escherichia coli small G-protein, binds to the 30S ribosomal subunit.
Biochem Biophys Res Commun. 1999 Oct 14;264(1):51-4. doi: 10.1006/bbrc.1999.1471.
6
The widely conserved Era G-protein contains an RNA-binding domain required for Era function in vivo.
Mol Microbiol. 1999 Sep;33(6):1118-31. doi: 10.1046/j.1365-2958.1999.01553.x.
7
The ripX locus of Bacillus subtilis encodes a site-specific recombinase involved in proper chromosome partitioning.
J Bacteriol. 1999 Oct;181(19):6053-62. doi: 10.1128/JB.181.19.6053-6062.1999.
8
Cloning and analysis of the rnc-era-recO operon from Pseudomonas aeruginosa.
J Bacteriol. 1999 Aug;181(16):5111-3. doi: 10.1128/JB.181.16.5111-5113.1999.
9
Crystal structure of ERA: a GTPase-dependent cell cycle regulator containing an RNA binding motif.
Proc Natl Acad Sci U S A. 1999 Jul 20;96(15):8396-401. doi: 10.1073/pnas.96.15.8396.
10
Biochemical and molecular analyses of the C-terminal domain of Era GTPase from Streptococcus pneumoniae.
Microbiology (Reading). 1999 Apr;145 ( Pt 4):791-800. doi: 10.1099/13500872-145-4-791.

文献AI研究员

20分钟写一篇综述,助力文献阅读效率提升50倍。

立即体验

用中文搜PubMed

大模型驱动的PubMed中文搜索引擎

马上搜索

文档翻译

学术文献翻译模型,支持多种主流文档格式。

立即体验