Kuh Diana, Hardy Rebecca, Langenberg Claudia, Richards Marcus, Wadsworth Michael E J
Medical Research Council National Survey of Health and Development, Department of Epidemiology and Public Health, Royal Free and University College London, London WC1E 6BT.
BMJ. 2002 Nov 9;325(7372):1076-80. doi: 10.1136/bmj.325.7372.1076.
To examine premature mortality in adults in relation to socioeconomic conditions in childhood and adulthood.
Nationally representative birth cohort study with prospective information on socioeconomic conditions.
England, Scotland, and Wales. STUDY MEMBERS: 2132 women and 2322 men born in March 1946 and followed until age 55 years.
Deaths between 26 and 54 years of age notified by the NHS central register.
Study members whose father's occupation was manual at age 4, or who lived in the worst housing, or who received the poorest care in childhood had double the death rate during adulthood of those living in the best socioeconomic conditions. All indicators of socioeconomic disadvantage at age 26 years, particularly lack of home ownership, were associated with a higher death rate. Manual origins and poor care in childhood remained associated with mortality even after adjusting for social class in adulthood or home ownership. The hazard ratio was 2.6 (95% confidence interval 1.5 to 4.4) for those living in manual households as children and as adults compared with those living in non-manual households at both life stages. The hazard ratio for those from manual origins who did not own their own home at age 26 years was 4.9 (2.3 to 10.5) compared with those from non-manual origins who were home owners.
Socioeconomic conditions in childhood as well as early adulthood have strongly influenced the survival of British people born in the immediate post war era.
研究成年人过早死亡与童年及成年期社会经济状况的关系。
具有全国代表性的出生队列研究,前瞻性收集社会经济状况信息。
英格兰、苏格兰和威尔士。
1946年3月出生的2132名女性和2322名男性,随访至55岁。
英国国民医疗服务体系中央登记处通报的26至54岁之间的死亡情况。
父亲在其4岁时从事体力劳动、童年居住条件最差或接受护理最差的研究对象,其成年期死亡率是社会经济状况最佳者的两倍。26岁时所有社会经济劣势指标,尤其是无自有住房,均与较高死亡率相关。即使在对成年期社会阶层或自有住房情况进行调整后,童年期的体力劳动者出身和较差护理仍与死亡率相关。儿童期和成年期均生活在体力劳动者家庭的人与两个阶段均生活在非体力劳动者家庭的人相比,风险比为2.6(95%置信区间1.5至4.4)。26岁时无自有住房的体力劳动者出身者与自有住房的非体力劳动者出身者相比,风险比为4.9(2.3至10.5)。
童年期以及成年早期的社会经济状况对二战后不久出生的英国人的生存有强烈影响。