2型糖尿病中的胰岛淀粉样变：临床与历史回顾

Pancreatic islet amyloid in type 2 diabetes mellitus: a clinical and historical review.

作者信息

Hayden M R

机构信息

Camdenton Community Health Center, Department of Cardiovascular Atherosclerosis, Metabolism and Aging, Department of Family and Community Medicine, University of Missouri-Columbia, USA.

出版信息

Mo Med. 2002 Sep-Oct;99(9):495-8.

PMID:12462941

Abstract

In 1901 Eugene L. Opie, MD, a Dean of Washington University School of Medicine (Figure 1) described the histologic presence of amyloid within the pancreatic islets of patients with type 2 diabetes mellitus. Although amyloid is present in at least 70 percent of type 2 diabetic patients, the subject has not been clinically emphasized. This paper reviews the history of Opie's discovery and current clinical implications of islet amyloid.

摘要

1901年，华盛顿大学医学院院长尤金·L·奥皮医学博士（图1）描述了2型糖尿病患者胰岛内淀粉样蛋白的组织学存在情况。尽管至少70%的2型糖尿病患者存在淀粉样蛋白，但该问题在临床上并未得到重视。本文回顾了奥皮发现的历史以及胰岛淀粉样蛋白目前的临床意义。