牛24号染色体的共识和综合连锁图谱。

Consensus and comprehensive linkage maps of bovine chromosome 24.

作者信息

Kurar E, Barendse W, Bottema C D K, Davis S, Föster M, Kalm E, Kappes S M, Kister A, Lewin H A, Klungland H, Medjugorac I, Olsaker I, Pitchford W S, Schmutz S M, Taylor J, Thomsen H, Kirkpatrick B W

机构信息

Department of Animal Sciences, University of Wisconsin-Madison, Madison, WI 53706, USA.

出版信息

Anim Genet. 2002 Dec;33(6):460-3. doi: 10.1046/j.1365-2052.2002.00909.x.

DOI:10.1046/j.1365-2052.2002.00909.x

PMID:12464023

Abstract

This study describes development of a consensus genetic linkage map of bovine chromosome 24 (BTA24). Eight participating laboratories contributed data for 58 unique markers including a total of 25 409 meioses. Eighteen markers, which were typed in more than one reference population, were used as potential anchors to generate a consensus framework map. The framework map contained 16 loci ordered with odds greater than 1000:1 and spanned 79.3 cM. Remaining markers were included in a comprehensive map relative to these anchors. The resulting BTA24 comprehensive map was 98.3 cM in length. Average marker intervals were 6.1 and 2.5 cM for framework and comprehensive maps, respectively. Marker order was generally consistent with previously reported BTA24 linkage maps. Only one discrepancy was found when comparing the comprehensive map with the published USDA-MARC linkage map. Integration of genetic information from different maps provides a high-resolution BTA24 linkage map.

摘要

本研究描述了牛24号染色体（BTA24）一致性遗传连锁图谱的构建。八个参与实验室提供了58个独特标记的数据，共包括25409个减数分裂。在多个参考群体中进行分型的18个标记被用作潜在锚定标记，以生成一个一致性框架图谱。该框架图谱包含16个排序后优势比大于1000:1的位点，跨度为79.3厘摩。其余标记相对于这些锚定标记被纳入一个完整图谱。最终得到的BTA24完整图谱长度为98.3厘摩。框架图谱和完整图谱的平均标记间隔分别为6.1厘摩和2.5厘摩。标记顺序总体上与先前报道的BTA24连锁图谱一致。将该完整图谱与已发表的美国农业部-肉类动物研究中心（USDA-MARC）连锁图谱进行比较时，仅发现一处差异。整合来自不同图谱的遗传信息可提供一个高分辨率的BTA24连锁图谱。