一种在多能间充质祖细胞中具有成骨诱导活性的小分子。
A small molecule with osteogenesis-inducing activity in multipotent mesenchymal progenitor cells.
作者信息
Wu Xu, Ding Sheng, Ding Qiang, Gray Nathanael S, Schultz Peter G
机构信息
Department of Chemistry and the Skaggs Institute for Chemical Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, USA.
出版信息
J Am Chem Soc. 2002 Dec 11;124(49):14520-1. doi: 10.1021/ja0283908.
Purmorphamine, which is a 2,6,9-trisubstituted purine compound, was discovered through cell-based high-throughput screening from a heterocycle combinatorial library. It differentiates multipotent mesenchymal progenitor cells into an osteoblast lineage. It will serve as a unique chemical tool to study the molecular mechanisms of osteogenesis of stem cells and bone development.
嘌呤吗啡啉是一种2,6,9-三取代嘌呤化合物，通过基于细胞的高通量筛选从杂环组合文库中发现。它能将多能间充质祖细胞分化为成骨细胞谱系。它将作为一种独特的化学工具来研究干细胞成骨和骨骼发育的分子机制。
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