Deugnier Marie-Ange, Teulière Jérôme, Faraldo Marisa M, Thiery Jean Paul, Glukhova Marina A
UMR 144 CNRS-Institut Curie, Section de Recherche, Paris, France.
Breast Cancer Res. 2002;4(6):224-30. doi: 10.1186/bcr459. Epub 2002 Aug 19.
The mammary myoepithelial cell was named the 'Cinderella of mammary cell biology' in light of the earlier focus on the luminal cell. Mammary myoepithelial cells have recently been described as 'natural tumour suppressors'. We now need to understand more about their origin and to reconsider their place in the complex process of mammary morphogenesis. In the present review, we discuss the lineage segregation of mammary myoepithelial cells and their functions in mammary gland development. These functions include their effects on luminal cell growth and differentiation, their key role in the establishment of the polarised mammary epithelial bilayer and the control of stromal invasion in breast cancer.
鉴于早期对腔上皮细胞的关注,乳腺肌上皮细胞被称为“乳腺细胞生物学的灰姑娘”。乳腺肌上皮细胞最近被描述为“天然肿瘤抑制因子”。我们现在需要更多地了解它们的起源,并重新审视它们在乳腺形态发生这一复杂过程中的地位。在本综述中,我们讨论了乳腺肌上皮细胞的谱系分离及其在乳腺发育中的功能。这些功能包括它们对腔上皮细胞生长和分化的影响、它们在极化乳腺上皮双层结构建立中的关键作用以及对乳腺癌中基质侵袭的控制。