Xiao Zhijian, Hao Yushu, Qin Tiejun, Han Zhongchao
Department of Clinical Hematology, Institute of Hematology, Chinese Academy of Medical Sciences and Peking Union Medical College, 288 Nanjing Road, 300020, Tianjin, PR China.
Leuk Res. 2003 Jan;27(1):89-91. doi: 10.1016/s0145-2126(02)00097-8.
Chronic eosinophilic leukemia (CEL) is a rare myeloproliferative disease in which autonomous, clonal proliferation of eosinophilic precursors results in persistent increase of eosinophils in the blood and bone marrow. A case of CEL spontaneous oscillation of white blood cell (WBC) count is presented. The cycle of WBC variation comprised about 60 days. Similar cyclic variations were noted in his platelet count, hemoglobin level and bone marrow cellularity, as well as in the spleen size, which was directly correlated with the WBC count. The numbers of bone marrow erythroid colony-forming units (CFU-E), granulocyte-macrophage colony-forming units (CFU-GM) and the serum level of colony-stimulating factors (CSFs) were also regularly changed during the oscillation of WBC. Bone marrow hyperplasia was accompanied with the increase in peripheral WBC count, suggesting that the variation of cell production caused the cyclic oscillation.
慢性嗜酸性粒细胞白血病（CEL）是一种罕见的骨髓增殖性疾病，其中嗜酸性粒细胞前体的自主克隆增殖导致血液和骨髓中嗜酸性粒细胞持续增加。本文报告一例慢性嗜酸性粒细胞白血病患者白细胞（WBC）计数自发振荡的病例。白细胞变化周期约为60天。其血小板计数、血红蛋白水平、骨髓细胞密度以及脾脏大小也出现类似的周期性变化，且脾脏大小与白细胞计数直接相关。在白细胞振荡期间，骨髓红系集落形成单位（CFU-E）、粒-巨噬细胞集落形成单位（CFU-GM）数量以及集落刺激因子（CSF）血清水平也有规律地变化。骨髓增生伴随着外周血白细胞计数增加，提示细胞生成的变化导致了周期性振荡。
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