[结直肠癌肝转移的治疗]

[Treatment of colorectal cancer--hepatic metastases].

作者信息

Makino Harufumi, Miyazaki Shinichi, Okazumi Shinichi, Matsushita Kazuyuki, Miura Fumihiko, Cho Akihiro, Yoshinaga Yushin, Ohira Gaku, Kudo Hidehiro, Tohma Takayuki, Matsubara Katsuhiko, Gunji Yoshio, Hayashi Hideki, Akutsu Naotake, Ochiai Takenori

机构信息

Dept. of Academic Surgery, Graduate School of Medicine, Chiba University.

出版信息

Gan To Kagaku Ryoho. 2002 Nov;29(12):2447-9.

PMID:12484096

Abstract

The aim of this study was to evaluate the effect of the local therapy for colorectal liver metastases on overall survival. Seventy-two patients who had resected liver metastases from colorectal cancer during the period from 1982 to 2001 were evaluated for survival. There was no significant difference in overall survival by either surgical method for colorectal liver metastases or postoperative arterial infusion chemotherapy. However, the 5-year survival rate of resected metachronous liver metastases with postoperative arterial infusion chemotherapy was 44.9%, and that for patients with no extra hepatic metastases was 57.4%. Patients who have metachronous liver metastases from colorectal cancer should therefore be considered for postoperative arterial infusion chemotherapy. It is necessary to improve the outcome for cases that have extra hepatic metastases.

摘要

本研究的目的是评估结直肠癌肝转移局部治疗对总生存期的影响。对1982年至2001年期间因结直肠癌行肝转移灶切除的72例患者的生存情况进行了评估。结直肠癌肝转移的手术方法或术后动脉灌注化疗对总生存期均无显著差异。然而，术后动脉灌注化疗的异时性肝转移灶切除患者的5年生存率为44.9%，无肝外转移患者的5年生存率为57.4%。因此，对于结直肠癌异时性肝转移患者应考虑术后动脉灌注化疗。改善有肝外转移病例的治疗效果很有必要。