Janssen I, Hanssen M, Bak M, Bijl R V, de Graaf R, Vollebergh W, McKenzie K, van Os J
Department of Psychiatry and Neuropsychology, Maastricht University, The Netherlands.
Br J Psychiatry. 2003 Jan;182:71-6. doi: 10.1192/bjp.182.1.71.
In the UK and The Netherlands, people with high rates of psychosis are chronically exposed to discrimination.
To test whether perceived discrimination is associated longitudinally with onset of psychosis.
A 3-year prospective study of cohorts with no history of psychosis and differential rates of reported discrimination on the basis of age, gender, disability, appearance, skin colour or ethnicity and sexual orientation was conducted in the Dutch general population (n=4076). The main outcome was onset of psychotic symptoms (delusions and hallucinations).
The rate of delusional ideation was 0.5% (n=19) in those who did not report discrimination, 0.9% (n=4) in those who reported discrimination in one domain, and 2.7% (n=3) in those who reported discrimination in more than one domain (exact P=0.027). This association remained after adjustment for possible confounders. No association was found between baseline discrimination and onset of hallucinatory experiences.
Perceived discrimination may induce delusional ideation and thus contribute to the high observed rates of psychotic disorder in exposed minority populations.
在英国和荷兰,精神病发病率较高的人群长期遭受歧视。
检验感知到的歧视是否与精神病的发病存在纵向关联。
在荷兰普通人群(n = 4076)中开展了一项为期3年的前瞻性研究,研究对象为无精神病病史且基于年龄、性别、残疾、外貌、肤色或种族以及性取向存在不同程度歧视报告率的队列。主要结局为精神病症状(妄想和幻觉)的出现。
未报告遭受歧视的人群中妄想观念发生率为0.5%(n = 19),报告在一个领域遭受歧视的人群中发生率为0.9%(n = 4),报告在多个领域遭受歧视的人群中发生率为2.7%(n = 3)(确切P = 0.027)。在对可能的混杂因素进行调整后,这种关联仍然存在。未发现基线歧视与幻觉体验的发生之间存在关联。
感知到的歧视可能诱发妄想观念,从而导致在受影响的少数人群中观察到的高精神病发病率。