海马体兴奋性过高会促进大鼠杏仁核点燃效应。

Mirnajafi-Zadeh J, Pourgholami M H

Department of Physiology, School of Medical Sciences, Tarbiat Modarres University, P. O. Box 14115-111, Tehran, I.R. Iran.

Indian J Med Res. 2002 Jul;116:35-40.

BACKGROUND & OBJECTIVES: The amygdala and hippocampus are recognized as the two important structures in the brain involved in the development and control of kindled seizures. The study on the precise interconnection between these two regions can provide important insights into the functional anatomy of complex partial seizures. In this study the effect of an experimentally increased excitability in hippocampal neurons, via hippocampal kindling, on the amygdala kindling rate was investigated in rats.

METHODS

Animals were divided into four groups. Tripolar electrodes were implanted in the amygdala and CA1 region of the dorsal hippocampus of animals of Groups 1, 3 and 4. In Group 2 animals, tripolar electrodes were only implanted in the amygdala. In Group 1, one week after surgery, the rats were kindled first from the hippocampus and the next day kindled by amygdala stimulation. In Groups 2 and 3, one week after surgery, rats were kindled from the amygdala. Group 4 animals had a recovery period of one week plus 32 days, which was the mean of the hippocampal kindling rate in Group 1, and then were kindled from the amygdala.

RESULTS

In Group 1, the amygdala kindling rate (n; number of days for which animals were stimulated before a stage 5 motor convulsion is triggered) and seizure stage at day n/2 were significantly facilitated and increased respectively. There was also a significant positive correlation between hippocampal and amygdala kindling rates.

INTERPRETATION & CONCLUSION: Results obtained show that an increase in hippocampal excitability can facilitate kindling from the amygdala. Thus, it is suggested that the hippocampus has an important role in the development and propagation of seizures from the amygdala.

背景与目的

杏仁核和海马体被认为是大脑中参与点燃性癫痫发作发展和控制的两个重要结构。对这两个区域之间精确互连的研究可以为复杂部分性癫痫发作的功能解剖学提供重要见解。在本研究中，通过海马体点燃实验性增加海马神经元兴奋性对大鼠杏仁核点燃率的影响进行了研究。

方法

将动物分为四组。在第1、3和4组动物的杏仁核和背侧海马体的CA1区域植入三极电极。在第2组动物中，仅在杏仁核植入三极电极。在第1组中，手术后一周，大鼠首先从海马体开始点燃，第二天通过杏仁核刺激进行点燃。在第2和3组中，手术后一周，大鼠从杏仁核开始点燃。第4组动物有一周加32天的恢复期，这是第1组海马体点燃率的平均值，然后从杏仁核开始点燃。