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[基于四核苷酸串联重复序列LPL、vWA和TH01的分子遗传学个体化系统在俄罗斯人群中的等位基因多态性]

[Allele polymorphism of molecular-genetic individualizing systems based on tetranucleotide tandem repeats LPL, vWA and TH01 among the population of Russia].

作者信息

Kornienko I V, Zemskova E Iu, Frolova S A, Iakushev V V, Ivanov P L

出版信息

Sud Med Ekspert. 2002 Sep-Oct;45(5):12-4.

Abstract

Until recently, data bases on incidence rates of alleles STR (LPL, vWA and THO1 loci) have not been introduced in Russia. To obtain information on the above rates in Russia, a large scale research of distribution of LPL, vWA and Tho1 loci has been performed among a sample of 442 blood-unrelated persons from 57 regions of the Russian Federation to specify basic assessment characteristics of these loci and to raise efficiency of expert use of identifying systems on their base. Relevant parameters (allele frequencies) are presented for each polymorphic locus as well as basic population characteristics of polymorphism in the studied sample of RF population. These results can be used as key parameters for standard probability estimations in assessing the results of molecular-genetic identification.

摘要

直到最近,俄罗斯尚未引入关于等位基因STR(脂蛋白脂肪酶、可变数目串联重复序列和组织相容性抗原1位点)发生率的数据库。为了获取俄罗斯上述发生率的信息,在来自俄罗斯联邦57个地区的442名无血缘关系人员的样本中,对脂蛋白脂肪酶、可变数目串联重复序列和组织相容性抗原1位点的分布进行了大规模研究,以明确这些位点的基本评估特征,并提高基于这些位点的识别系统的专家使用效率。针对每个多态性位点给出了相关参数(等位基因频率)以及俄罗斯联邦人群研究样本中多态性的基本群体特征。这些结果可作为评估分子遗传学鉴定结果时标准概率估计的关键参数。

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