Hurrell Richard, Bothwell Thomas, Cook James D, Dary Omar, Davidsson Lena, Fairweather-Tait Susan, Hallberg Leif, Lynch Sean, Rosado Jorge, Walter Tomas, Whittaker Paul
Swiss Federal Institute of Technology, Zürich, Switzerland.
Nutr Rev. 2002 Dec;60(12):391-406. doi: 10.1301/002966402320964061.
Fortification of cereal flours may be a useful public health strategy to combat iron deficiency. Cereal flours that are used shortly after production (e.g., baking flour) can be fortified with soluble iron compounds, such as ferrous sulfate, whereas the majority of flours stored for longer periods is usually fortified with elemental iron powders to avoid unacceptable sensory changes. Elemental iron powders are less well absorbed than soluble iron compounds and they vary widely in their absorption depending on manufacturing method and physicochemical characteristics. Costs vary with powder type, but elemental iron powders are generally less expensive than ferrous sulfate. This review evaluates the usefulness of the different elemental iron powders based on results from in vitro studies, rat assays, human bioavailability studies, and efficacy studies monitoring iron status in human subjects. It concludes that, at the present time, only electrolytic iron powder can be recommended as an iron fortificant. Because it is only approximately half as well absorbed as ferrous sulfate, it should be added to provide double the amount of iron.
谷物面粉强化可能是对抗缺铁的一项有益公共卫生策略。生产后不久即使用的谷物面粉(如烘焙面粉)可用硫酸亚铁等可溶性铁化合物进行强化,而大多数储存较长时间的面粉通常用元素铁粉强化以避免出现不可接受的感官变化。元素铁粉的吸收不如可溶性铁化合物好,并且其吸收因制造方法和物理化学特性而异。成本因粉末类型而异,但元素铁粉通常比硫酸亚铁便宜。本综述根据体外研究、大鼠试验、人体生物利用度研究以及监测人体受试者铁状态的功效研究结果,评估了不同元素铁粉的效用。结论是,目前仅推荐电解铁粉作为铁强化剂。由于其吸收量仅约为硫酸亚铁的一半,因此应添加双倍量的铁。