给予吗啡并在11个绝对大气压下接受氦氧混合气处理的大鼠血液成分的变化。

Changes in blood constituents in rats administered morphine and subjected to He-O2 at 11 ATA.

作者信息

De Boer B, Tofano M

出版信息

Aviat Space Environ Med. 1976 Feb;47(2):151-3.

Abstract

Changes in blood constituents in rats exposed to He-O2 at 1 ATA and 11 ATA after administration of morphine (100 mg/kg) are reported. Injected animals are compared with controls (non-injected) in ambient air and animals subjected to He-O2 at 1 ATA and 11 ATA. Temperature of the chamber was controlled and O2 partial pressure and CO2 levels were maintained at standard conditions. After morphine injection the rats were pressurized and maintained for 4 h before decompression, at which time additional blood samples were obtained. Morphine-injected animals in ambient air showed significant decreases in hematocrit, MCV, glucose, and protein in the blood while showing an increase in the leukocyte count and blood potassium. Non-injected animals maintained in He-O2 at 1 ATA and 11 ATA showed no deviation from ambient air control animals. Injected animals in He-O2 at 1 ATA showed no changes from those in ambient air, but animals injected and exposed to 11 ATA did not have a decreased serum protein level or an increase in potassium.

摘要

报告了给予吗啡（100mg/kg）后，在1个绝对大气压（ATA）和11个ATA下暴露于氦氧混合气的大鼠血液成分的变化。将注射了吗啡的动物与在环境空气中的对照（未注射）动物以及在1个ATA和11个ATA下接受氦氧混合气的动物进行比较。控制舱内温度，并将氧气分压和二氧化碳水平维持在标准条件。注射吗啡后，对大鼠进行加压并在减压前维持4小时，此时采集额外的血样。在环境空气中注射吗啡的动物血液中的血细胞比容、平均红细胞体积、葡萄糖和蛋白质显著降低，而白细胞计数和血钾增加。在1个ATA和11个ATA下维持于氦氧混合气中的未注射动物与环境空气对照动物无差异。在1个ATA下处于氦氧混合气中的注射动物与在环境空气中的动物无变化，但注射并暴露于11个ATA的动物血清蛋白水平未降低，血钾也未增加。