[葫芦素聚乳酸纳米粒冻干注射剂的研究]
[A study on lyophilization injection of cucurbitacin polylactic acid nanoparticles].
作者信息
Li C Y, Hou S X
机构信息
School of Pharmacy, West China University of Medical Sciences, Chengdu 610041, Sichuan, China.
出版信息
Zhongguo Zhong Yao Za Zhi. 2001 May;26(5):315-7.
OBJECTIVE
To prepare stable and redispersable Lyophilization injection of cucurbitacin polylactic acid nanoparticles(Cu-PLA-NP).
METHOD
An optimal supporting agent was chosen to prepare the Cu-PLA-NP lyophilization injection. The physical and chemical properties of the injection were evaluated.
RESULTS
The shape, diameters, association ratio, drug loading and pH of Cu-PLA-NP colloidal solution and lyophilization injection were not changed. The content of water consisted with the requirement of lyophilization injection. The critical relative humidity was 69.52%. The stability was good.
CONCLUSION
It is practicable to prepare Cu-PLA-NP lyophilization injection with proper formulas and preparation processes.
目的
制备稳定且可再分散的葫芦素聚乳酸纳米粒冻干注射剂（Cu-PLA-NP）。
方法
选择一种最佳的支撑剂来制备Cu-PLA-NP冻干注射剂。对该注射剂的理化性质进行评估。
结果
Cu-PLA-NP胶体溶液及冻干注射剂的形状、粒径、缔合率、载药量和pH值均未改变。水分含量符合冻干注射剂的要求。临界相对湿度为69.52%。稳定性良好。
结论
采用合适的配方和制备工艺制备Cu-PLA-NP冻干注射剂是可行的。
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