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[心肌细胞肥大中的信号转导通路]

[Signal transduction pathways in cardiac myocyte hypertrophy].

作者信息

Fu M G, Tang C S

机构信息

Institute of Cardiovascular Research, First Hospital, Beijing Medical University, Beijing 100034.

出版信息

Sheng Li Ke Xue Jin Zhan. 2000 Jan;31(1):19-24.

Abstract

Cardiac hypertrophy is the consequence of hypertrophic stimulus-induced changes in gene expression, which is linked by intracellular signal transduction. It is likely, however, that there are "molecular phenotypic" differences underlying cardiac hypertrophy triggered by different stimuli, which is caused by the different signal pathways that they initiated. Studying on the signal pathways in cardiac myocyte hypertrophy contributed to elucidate the cellular and molecular mechanisms of cardiac hypertrophy and might find some new strategies for the prevention of cardiac hypertrophy.

摘要

心肌肥大是由肥厚刺激诱导的基因表达变化的结果,这种变化通过细胞内信号转导相联系。然而,不同刺激引发的心肌肥大可能存在“分子表型”差异,这是由它们启动的不同信号通路所致。对心肌细胞肥大信号通路的研究有助于阐明心肌肥大的细胞和分子机制,并可能找到预防心肌肥大的新策略。

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