Hillebrand J J G, de Wied D, Adan R A H
Department of Medical Pharmacology, Rudolf Magnus Institute for Neurosciences, Utrecht University, Universiteitsweg 100, 3584 CG Utrecht, The Netherlands.
Peptides. 2002 Dec;23(12):2283-306. doi: 10.1016/s0196-9781(02)00269-3.
Energy homeostasis is controlled by a complex neuroendocrine system consisting of peripheral signals like leptin and central signals, in particular, neuropeptides. Several neuropeptides with anorexigenic (POMC, CART, and CRH) as well as orexigenic (NPY, AgRP, and MCH) actions are involved in this complex (partly redundant) controlling system. Starvation as well as overfeeding lead to changes in expression levels of these neuropeptides, which act downstream of leptin, resulting in a physiological response. In this review the role of several anorexigenic and orexigenic (hypothalamic) neuropeptides on food intake and body weight regulation is summarized.
能量平衡由一个复杂的神经内分泌系统控制，该系统由瘦素等外周信号和中枢信号（特别是神经肽）组成。几种具有厌食作用（促黑素细胞激素原、可卡因-安非他明调节转录肽和促肾上腺皮质激素释放激素）以及食欲增强作用（神经肽Y、刺鼠肽基因相关蛋白和黑素细胞浓缩激素）的神经肽参与了这个复杂（部分冗余）的控制系统。饥饿和过度喂养都会导致这些神经肽表达水平的变化，这些神经肽在瘦素下游起作用，从而产生生理反应。在这篇综述中，总结了几种（下丘脑）厌食和促食欲神经肽在食物摄入和体重调节中的作用。
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