一个支持全基因组序列注释的集成计算流程和数据库。
An integrated computational pipeline and database to support whole-genome sequence annotation.
作者信息
Mungall C J, Misra S, Berman B P, Carlson J, Frise E, Harris N, Marshall B, Shu S, Kaminker J S, Prochnik S E, Smith C D, Smith E, Tupy J L, Wiel C, Rubin G M, Lewis S E
机构信息
Howard Hughes Medical Institute, University of California, Berkeley, CA 94720, USA.
出版信息
Genome Biol. 2002;3(12):RESEARCH0081. doi: 10.1186/gb-2002-3-12-research0081. Epub 2002 Dec 23.
We describe here our experience in annotating the Drosophila melanogaster genome sequence, in the course of which we developed several new open-source software tools and a database schema to support large-scale genome annotation. We have developed these into an integrated and reusable software system for whole-genome annotation. The key contributions to overall annotation quality are the marshalling of high-quality sequences for alignments and the design of a system with an adaptable and expandable flexible architecture.
我们在此描述了我们注释黑腹果蝇基因组序列的经验，在此过程中，我们开发了几个新的开源软件工具和一个数据库模式，以支持大规模的基因组注释。我们已将这些开发成一个用于全基因组注释的集成且可重复使用的软件系统。对整体注释质量的关键贡献在于整理用于比对的高质量序列，以及设计一个具有适应性和可扩展性的灵活架构的系统。
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