计算机模拟中的整合生物建模

Integrative biological modelling in silico.

作者信息

McCulloch Andrew D, Huber Gary

机构信息

Department of Bioengineering, The Whitaker Institute of Biomedical Engineering, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093-0412, USA.

出版信息

Novartis Found Symp. 2002;247:4-19; discussion 20-5, 84-90, 244-52.

PMID:12539946

Abstract

In silico models of biological systems provide a powerful tool for integrative analysis of physiological function. Using the computational models of the heart as examples, we discuss three types of integration: structural integration implies integration across physical scales of biological organization from protein molecule to whole organ; functional integration of interacting physiological processes such as signalling, metabolism, excitation and contraction; and the synthesis of experimental observation with physicochemical and mathematical principles.

摘要

生物系统的计算机模拟模型为生理功能的综合分析提供了一个强大的工具。以心脏的计算模型为例，我们讨论三种整合类型：结构整合意味着跨越从蛋白质分子到整个器官的生物组织物理尺度的整合；相互作用的生理过程（如信号传导、代谢、兴奋和收缩）的功能整合；以及将实验观察结果与物理化学和数学原理进行综合。