一项关于女性睡眠时间与冠心病的前瞻性研究。

A prospective study of sleep duration and coronary heart disease in women.

作者信息

Ayas Najib T, White David P, Manson JoAnn E, Stampfer Meir J, Speizer Frank E, Malhotra Atul, Hu Frank B

机构信息

Division of Pulmonary Medicine, Department of Medicine, Vancouver General Hospital, 2775 Heather St, Vancouver, British Columbia, Canada V5Z 3J5.

出版信息

Arch Intern Med. 2003 Jan 27;163(2):205-9. doi: 10.1001/archinte.163.2.205.

DOI:10.1001/archinte.163.2.205

PMID:12546611

Abstract

BACKGROUND

Long-term sleep deprivation is common in today's society. Recent experiments have demonstrated that short-term sleep deprivation in healthy subjects results in adverse physiologic changes, including a decreased glucose tolerance and an increased blood pressure. However, the long-term health consequences of long-term sleep deprivation are unclear. The objective of this study was to determine whether decreased sleep duration (from self-reports) is associated with an increased risk of coronary events.

METHODS

We studied a cohort of 71 617 US female health professionals (aged 45-65 years), without reported coronary heart disease (CHD) at baseline, who were enrolled in the Nurses' Health Study. Subjects were mailed a questionnaire in 1986 asking about daily sleep duration. Subjects were followed up until June 30, 1996, for the occurrence of CHD-related events. We assessed the relationship between self-reported sleep duration and incident CHD.

RESULTS

A total of 934 coronary events were documented (271 fatal and 663 nonfatal) during the 10 years of follow up. Age-adjusted relative risks (95% confidence intervals) of CHD (with 8 hours of daily sleep being considered the reference group) for individuals reporting 5 or fewer, 6, and 7 hours of sleep were 1.82 (1.34-2.41), 1.30 (1.08-1.57), and 1.06 (0.89-1.26), respectively. The relative risk (95% confidence interval) for 9 or more hours of sleep was 1.57 (1.18-2.11). After adjusting for various potential confounders, including snoring, body mass index, and smoking, the relative risks of CHD (95% confidence intervals) for individuals reporting 5 or fewer, 6, and 7 hours of sleep were 1.45 (1.10-1.92), 1.18 (0.98-1.42), and 1.09 (0.91-1.30), respectively. The relative risk (95% confidence interval) for 9 or more hours of sleep was 1.38 (1.03-1.86).

CONCLUSION

Short and long self-reported sleep durations are independently associated with a modestly increased risk of coronary events.

摘要

背景

长期睡眠剥夺在当今社会很常见。最近的实验表明，健康受试者短期睡眠剥夺会导致不良的生理变化，包括葡萄糖耐量降低和血压升高。然而，长期睡眠剥夺对健康的长期影响尚不清楚。本研究的目的是确定睡眠时间缩短（根据自我报告）是否与冠心病事件风险增加有关。

方法

我们研究了71617名美国女性健康专业人员（年龄在45 - 65岁之间）的队列，她们在基线时未报告患有冠心病（CHD），这些人参加了护士健康研究。1986年向受试者邮寄了一份问卷，询问每日睡眠时间。对受试者进行随访直至1996年6月30日，观察冠心病相关事件的发生情况。我们评估了自我报告的睡眠时间与冠心病发病之间的关系。

结果

在10年的随访期间，共记录了934例冠心病事件（271例致命，663例非致命）。以每日睡眠8小时作为参照组，报告睡眠5小时及以下、6小时和7小时的个体，年龄调整后的冠心病相对风险（95%置信区间）分别为1.82（1.34 - 2.41）、1.30（1.08 - 1.57）和1.06（0.89 - 1.26）。睡眠9小时及以上的相对风险（95%置信区间）为1.57（1.18 - 2.11）。在对包括打鼾、体重指数和吸烟等各种潜在混杂因素进行调整后，报告睡眠5小时及以下、6小时和7小时的个体，冠心病的相对风险（95%置信区间）分别为1.45（1.10 - 1.92）、1.18（0.98 - 1.42）和1.09（0.91 - 1.30）。睡眠9小时及以上的相对风险（95%置信区间）为1.38（1.03 - 1.86）。