Bacqué Eric, Pautrat François, Zard Samir Z
Laboratoire de Synthèse Organique associé au CNRS, Ecole Polytechnique, 91 128 Palaiseau Cedex, France.
Org Lett. 2003 Feb 6;5(3):325-8. doi: 10.1021/ol027312m.
[reaction: see text] A short synthesis of the tricyclic skeleton of pleuromutilin is reported, featuring an unusually efficient 8-endo-trig radical cyclization of a xanthate precursor. In the course of this study, a one-carbon ring expansion leading to cycloheptenes was uncovered.
[反应：见正文] 报道了截短侧耳素三环骨架的简短合成方法，其特点是黄原酸酯前体进行了异常高效的8-内型-三取代自由基环化反应。在该研究过程中，发现了一种导致环庚烯的单碳环扩展反应。
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