Wang Kai, Hoosain Rumjahn, Yang Ren-Min, Meng Yu, Wang Chang-Qing
Department of Neurology, First Affiliated Hospital of Anhui Medical University, Jixi Road, Anhui Province, Hefei, PR China.
Neuropsychologia. 2003;41(5):527-37. doi: 10.1016/s0028-3932(02)00171-9.
The selective involvement of the basal ganglia in recognition of the facial expression of disgust was investigated by examining a group of six symptomatic Huntington's disease patients and 32 Wilson's disease patients in China. Morphed photographs of facial expressions covering happiness-surprise-fear-sadness-disgust-anger were used and the patients were asked to label each photo. Other measures assessed basic cognitive functions and perception of non-emotion facial information, such as perception of gender, age, gaze direction, and recognition of unfamiliar as well as famous people. There was dissociation between the perception of emotions and other facial information, and between impairment of recognition of disgust and other emotions. The basal ganglia are the overlapping substrate involved in both Huntington's and Wilson's disease, although each has its own other lesions. The differentially severe impairment of recognition of disgust in the Chinese Huntington's disease and Wilson's disease patients strengthens the view that basal ganglia are selectively involved in processing the emotion of disgust.
通过对中国一组6名有症状的亨廷顿舞蹈症患者和32名威尔逊氏病患者进行检查，研究了基底神经节在识别厌恶面部表情中的选择性参与情况。使用了涵盖快乐-惊讶-恐惧-悲伤-厌恶-愤怒的面部表情变形照片，并要求患者为每张照片贴上标签。还采用了其他测量方法来评估基本认知功能以及对非情感面部信息的感知，比如对性别、年龄、注视方向的感知，以及对陌生人和名人的识别。在情绪感知与其他面部信息的感知之间，以及在厌恶识别障碍与其他情绪识别障碍之间，存在分离现象。基底神经节是亨廷顿舞蹈症和威尔逊氏病共同涉及的重叠基质，尽管每种疾病还有其他各自的病变。中国亨廷顿舞蹈症和威尔逊氏病患者在厌恶识别方面存在不同程度的严重损伤，这强化了基底神经节选择性参与处理厌恶情绪的观点。
