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[阻塞性睡眠呼吸暂停低通气综合征的诊断与治疗:西班牙纳瓦拉地区的情况]

[Diagnosis and treatment of obstructive sleep apnea-hypopnea syndrome: the situation in Navarra (Spain)].

作者信息

Hueto J, Boldú J, Cebollero P, Cascante J A, Abu-Shams J, Eguía V M, Esandi N

机构信息

Sección de Neumología. Hospital Virgen del Camino. Pamplona. Navarra. España.

出版信息

Arch Bronconeumol. 2002 Dec;38(12):554-60. doi: 10.1016/s0300-2896(02)75290-3.

Abstract

OBJECTIVE

To assess the diagnosis and treatment of obstructive sleep apnea-hypopnea syndrome (OSAHS) in Navarra (Spain) and to know the characteristics of patients treated with nasal continuous positive airway pressure (n-CPAP) in our community.

METHOD

All patients receiving nasal n-CPAP from the public health service of Navarra in July 2000 were enrolled. A nurse visited each patient and filled in a form with epidemiological data, and patient and clinical characteristics. The nurse then measured CO in expired air and the n-CPAP pressure used and recorded the hour counter reading on the n-CPAP device. Between one and two months later and without prior warning, the patient was once again contacted and a second visit was made. The counter was read again and expired CO was measured.

RESULTS

The prevalence of treatment with n-CPAP in Navarra was 125/100,000 inhabitants, and a gradual increase in annual prescriptions was observed. Home visits were made to 535 patients (80.7% of the total). Pneumologists wrote 83.5% of the prescriptions. n-CPAP was used a mean 6.1 hours/day, and the numbers of declared and real hours of use were statistically correlated. The mean apnea-hypopnea index was 51.5, although results were not available for 4.2% of the patients. The treatment was well tolerated according to 83.7% of the patients and 24.8% had been following it for over four years. The pathology most often associated with OSAHS was obesity (73.4% of the patients), followed by high blood pressure (40%); 299 patients (55.8%) had two or more associated diseases and 54 (9.7%) had none. Conventional polysomnography was the diagnostic method used in 45.9% of the cases, and respiratory polygraphs were available for 49.7%. Pressure was adjusted with the aid of polysomnography for 19.4% patients, whereas 32.1% had undergone no testing. Side effects of treatment were reported by 50.8%.

CONCLUSIONS

a) The prevalence of n-CPAP treatment in Navarra is high and prescriptions are increasing; b) patient tolerance of and compliance with therapy are good, c) polysomnographs or respiratory polygraphs are available for diagnosis of OSAHS in most cases but the n-CPAP pressure level is adjusted without the recommended studies for many patients.

摘要

目的

评估西班牙纳瓦拉地区阻塞性睡眠呼吸暂停低通气综合征(OSAHS)的诊断和治疗情况,并了解本社区接受鼻持续气道正压通气(n-CPAP)治疗患者的特征。

方法

纳入2000年7月在纳瓦拉公共卫生服务机构接受鼻n-CPAP治疗的所有患者。一名护士走访每位患者,填写一份包含流行病学数据、患者及临床特征的表格。然后护士测量呼出气体中的一氧化碳(CO)以及使用的n-CPAP压力,并记录n-CPAP设备上的小时计数器读数。在一到两个月后且无事先通知的情况下,再次联系患者并进行第二次走访。再次读取计数器读数并测量呼出的CO。

结果

纳瓦拉地区n-CPAP治疗的患病率为每10万居民中有125人,且观察到年度处方量逐渐增加。对535名患者(占总数的80.7%)进行了家访。呼吸科医生开出了83.5%的处方。n-CPAP的平均使用时间为每天6.1小时,申报的使用小时数与实际使用小时数在统计学上具有相关性。平均呼吸暂停低通气指数为51.5,不过4.2%的患者没有相关结果。83.7%的患者表示对治疗耐受性良好,24.8%的患者已接受该治疗超过四年。与OSAHS最常相关的病症是肥胖(占患者的73.4%),其次是高血压(40%);299名患者(55.8%)有两种或更多相关疾病,54名患者(9.7%)没有相关疾病。45.9%的病例采用传统多导睡眠图作为诊断方法,49.7%的病例可进行呼吸多导记录。19.4%的患者借助多导睡眠图调整压力,而32.1%的患者未进行任何检测。50.8%的患者报告了治疗副作用。

结论

a)纳瓦拉地区n-CPAP治疗的患病率较高且处方量在增加;b)患者对治疗的耐受性和依从性良好;c)大多数情况下可使用多导睡眠图或呼吸多导记录来诊断OSAHS,但许多患者在未进行推荐研究的情况下就调整了n-CPAP压力水平。

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