He Y K, Song G C, Liu S X, Luo X S, Zhang X Y, Xu Y X, Yu X L, Yang R Q
Hunan Institute of Parasitic Diseases, Yueyang 414000.
Zhongguo Ji Sheng Chong Xue Yu Ji Sheng Chong Bing Za Zhi. 2001;19(5):265-7.
To observe the dynamics of antibodies and protection against Schistosoma japonicum infections in buffaloes after immunized with recombinant 26 kDa glutathione-S-transferase (reSjc26GST).
Buffaloes in 2 villages endemic for schistosomiasis japonica were selected as test and control groups, respectively. In test group initially 96 buffaloes were vaccinated with reSjc26GST, and 90 buffaloes in the control group did not experience vaccination. The indicators included levels of antibodies to reSjc26GST in buffaloes before and after infection with S. japonicum and changes in infection rate.
Specific antibodies, which showed a trend of trapezoid increase, were induced in buffaloes after immunized with reSjc26GST. Twenty months after immunization, the infection rate of the test group was decreased by 62.2% when compared with that before vaccination, and by 67.7% when compared with that of the control in the corresponding period.
Specific antibodies and a certain extent of protection were induced in buffaloes after immunized with reSjc26GST, which played an significant role in ameliorating morbidity.
观察重组26 kDa谷胱甘肽-S-转移酶（reSjc26GST）免疫水牛后抗日本血吸虫感染的抗体动态及保护作用。
分别选取日本血吸虫病流行的2个村庄的水牛作为试验组和对照组。试验组最初96头水牛用reSjc26GST进行疫苗接种，对照组90头水牛未接种。指标包括水牛感染日本血吸虫前后针对reSjc26GST的抗体水平及感染率变化。
用reSjc26GST免疫水牛后诱导产生了呈梯形上升趋势的特异性抗体。免疫20个月后，试验组感染率与接种疫苗前相比下降了62.2%，与同期对照组相比下降了67.7%。
用reSjc26GST免疫水牛后可诱导产生特异性抗体及一定程度的保护作用，对减轻发病程度具有重要作用。
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