Ras/Raf/MEK/ERK信号通路对细胞周期进程和细胞凋亡的调控（综述）
Regulation of cell cycle progression and apoptosis by the Ras/Raf/MEK/ERK pathway (Review).
作者信息
Chang Fumin, Steelman Linda S, Shelton John G, Lee John T, Navolanic Patrick M, Blalock William L, Franklin Richard, McCubrey James A
机构信息
Department of Microbiology and Immunology, Brody School of Medicine at East Carolina University, Greenville, NC 27858, USA.
出版信息
Int J Oncol. 2003 Mar;22(3):469-80.
The Ras/Raf/MEK/ERK signal transduction pathway regulates cell cycle progression and apoptosis in diverse types of cells. Mutations in this pathway are often observed in transformed cell lines and frequently linked with human cancers. The Ras/Raf/MEK/ERK pathway can induce events both associated with cell proliferation and cell cycle arrest. The particular course chosen may depend on the strength and the particular Raf gene activated by Ras. This pathway also is involved in maintaining cell survival by modulating the activity of apoptotic molecules including Bad and Bcl-2. This review will discuss the regulation of the Ras/Raf/MEK/ERK pathway and how it modulates cell cycle progression and cell survival.
Ras/Raf/MEK/ERK信号转导通路调控多种类型细胞的细胞周期进程和凋亡。该通路的突变在转化细胞系中经常被观察到，并且常常与人类癌症相关联。Ras/Raf/MEK/ERK通路既能诱导与细胞增殖相关的事件，也能诱导细胞周期停滞。所选择的特定进程可能取决于Ras激活的信号强度和特定的Raf基因。该通路还通过调节包括Bad和Bcl-2在内的凋亡分子的活性来参与维持细胞存活。本综述将讨论Ras/Raf/MEK/ERK通路的调控以及它如何调节细胞周期进程和细胞存活。
Zotero 插件