秀丽隐杆线虫，一种具有高通量能力的衰老模型。

C. elegans, a model for aging with high-throughput capacity.

作者信息

Hertweck Maren, Hoppe Thorsten, Baumeister Ralf

机构信息

ABI/Molecular Neurogenetics, Ludwig-Maximilians-University Munich, Schillerstr. 44, D-80336 Munich, Germany.

出版信息

Exp Gerontol. 2003 Mar;38(3):345-6. doi: 10.1016/s0531-5565(02)00208-5.

DOI:10.1016/s0531-5565(02)00208-5

PMID:12581802

Abstract

The 1 mm long nematode Caenorhabditis elegans is one of the prime animal models to study the genetics of aging. Wild type animals under laboratory conditions live only for an average of 18 days, whereas mutations in about 50 genes have been identified that extend longevity up to sixfold. High-throughput analyses have been devised that allow large-scale analysis to identify additional genes, as well as compounds that affect life-span.

摘要

1毫米长的线虫秀丽隐杆线虫是研究衰老遗传学的主要动物模型之一。在实验室条件下，野生型动物平均仅存活18天，而现已鉴定出约50个基因的突变可使寿命延长至六倍。人们已经设计出高通量分析方法，用于大规模分析以鉴定其他基因以及影响寿命的化合物。