一个用于微小RNA注释的统一系统。
A uniform system for microRNA annotation.
作者信息
Ambros Victor, Bartel Bonnie, Bartel David P, Burge Christopher B, Carrington James C, Chen Xuemei, Dreyfuss Gideon, Eddy Sean R, Griffiths-Jones Sam, Marshall Mhairi, Matzke Marjori, Ruvkun Gary, Tuschl Thomas
机构信息
Dartmouth Medical School Department of Genetics, Hanover, New Hampshire 03755, USA.
出版信息
RNA. 2003 Mar;9(3):277-9. doi: 10.1261/rna.2183803.
Abstract
MicroRNAs (miRNAs) are small noncoding RNA gene products about 22 nt long that are processed by Dicer from precursors with a characteristic hairpin secondary structure. Guidelines are presented for the identification and annotation of new miRNAs from diverse organisms, particularly so that miRNAs can be reliably distinguished from other RNAs such as small interfering RNAs. We describe specific criteria for the experimental verification of miRNAs, and conventions for naming miRNAs and miRNA genes. Finally, an online clearinghouse for miRNA gene name assignments is provided by the Rfam database of RNA families.
摘要
微小RNA（miRNAs）是长度约为22个核苷酸的小型非编码RNA基因产物，由Dicer从前体加工而来，这些前体具有特征性的发夹二级结构。本文提出了从不同生物体中鉴定和注释新miRNAs的指导方针，特别是为了能够可靠地将miRNAs与其他RNA（如小干扰RNA）区分开来。我们描述了miRNAs实验验证的具体标准，以及miRNAs和miRNA基因命名的惯例。最后，RNA家族的Rfam数据库提供了一个miRNA基因名称分配的在线信息交换中心。
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