抗肿瘤药物在药房及医院工作人员中的摄取。第一部分：尿浓度监测。

Uptake of antineoplastic agents in pharmacy and hospital personnel. Part I: monitoring of urinary concentrations.

作者信息

Pethran Angelika, Schierl Rudolf, Hauff Karlheinz, Grimm Carl-Heinz, Boos Karl-Siegfried, Nowak Dennis

机构信息

Institute and Outpatient Clinic for Occupational and Environmental Medicine, Ludwig-Maximilians-University Munich, Ziemssenstrasse 1, 80336 Munich, Germany.

出版信息

Int Arch Occup Environ Health. 2003 Feb;76(1):5-10. doi: 10.1007/s00420-002-0383-8. Epub 2002 Oct 9.

DOI:10.1007/s00420-002-0383-8

PMID:12592576

Abstract

OBJECTIVES

There is a risk of adverse health effects for personnel with occupational exposure to antineoplastic agents. The aim of the present longitudinal study was to identify, quantify, and evaluate potential health hazards of occupationally exposed workers in pharmaceutical and oncological departments with central processing units for drug preparation.

METHODS

One hundred operatives in 14 German hospital pharmacies and oncological departments underwent biological monitoring by providing urine samples up to four times over a period of 3 years.

RESULTS

All antineoplastic agents that were considered (cyclophosphamide, ifosfamide, doxorubicin, epirubicin and platinum from cisplatin and carboplatin), were found in urine samples in up to 40% of participants.

CONCLUSIONS

Despite standard safety precautions, such as the use of vertical laminar air flow safety cabinets, and personal protective clothing, incorporation of drugs was detected. Therefore, an environmental monitoring strategy should be developed in order to detect contamination and attempt to improve hygiene during work.

摘要