锂和铷对小鼠静脉注射各种麻醉剂所致睡眠时间的影响。

Effect of lithium and rubidium on the sleeping time caused by various intravenous anaesthetics in the mouse.

作者信息

Männistö P T, Saarnivaara L

出版信息

Br J Anaesth. 1976 Mar;48(3):185-9. doi: 10.1093/bja/48.3.185.

DOI:10.1093/bja/48.3.185

Abstract

The effects of acute and long-term lithium (LiCl) and rubidium chloride (RbCl) treatments on the sleeping time caused by intravenous thipentone, methohexitone, ketamine, propanidid. Althesin and diazepam were studied in white mice. The doses of the anasthetic agents were selected from the dose-response experiments. When given acutely, LiCl 5 m-equiv/kg prolonged significantly the sleeping time caused by both of the barbiturates, whereas RbCl given for 21 days in tap water shortened the sleeping time induced by methohexitone and ketamine. Both LiCl and RbCl, given acutely, enhanced the sleeping time caused by diazepam. The rectal temperatures were lower in the LiCl-treated mice than in the control and RbCl-treated mice.

摘要

研究了急性和长期给予氯化锂（LiCl）和氯化铷（RbCl）对白鼠静脉注射硫喷妥钠、甲己炔巴比妥、氯胺酮、丙泮尼地、阿法沙龙和地西泮所致睡眠时间的影响。麻醉剂的剂量从剂量反应实验中选取。急性给予5 m当量/千克LiCl可显著延长两种巴比妥类药物所致的睡眠时间，而在自来水中给予21天的RbCl可缩短甲己炔巴比妥和氯胺酮诱导的睡眠时间。急性给予LiCl和RbCl均可延长地西泮所致的睡眠时间。LiCl处理组小鼠的直肠温度低于对照组和RbCl处理组小鼠。