由缺乏PorA的脑膜炎奈瑟菌引起的脑膜炎球菌病暴发。
Outbreak of meningococcal disease caused by PorA-deficient meningococci.
作者信息
van der Ende A, Hopman C T P, Keijzers W C M, Spanjaard L, Lodder E B, van Keulen P H J, Dankert J
机构信息
Department of Medical Microbiology, Academic Medical Center, PO Box 22700, 1100 DE Amsterdam, The Netherlands.
出版信息
J Infect Dis. 2003 Mar 1;187(5):869-71. doi: 10.1086/367899. Epub 2003 Feb 18.
An outbreak of 7 cases of group C meningococcal disease occurred during the last week of July and the first week of August 2001 in the southwestern part of The Netherlands. Characterization of the 7 patients' isolates by various typing methods showed that the isolates were identical, except for the expression of PorA. Isolates from 5 patients were PorA deficient. These results show that transmission of PorA-deficient meningococci occurs and that PorA-deficient meningococci can cause invasive disease. PorA-based meningococcal vaccines may provide limited protection.
2001年7月最后一周和8月第一周，荷兰西南部发生了一起7例C群脑膜炎球菌病疫情。通过各种分型方法对7名患者的分离株进行鉴定，结果显示，除了PorA的表达外，这些分离株是相同的。5名患者的分离株缺乏PorA。这些结果表明，缺乏PorA的脑膜炎球菌会发生传播，并且缺乏PorA的脑膜炎球菌可导致侵袭性疾病。基于PorA的脑膜炎球菌疫苗可能提供有限的保护。
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