[乙醇对成年蟾蜍神经肌肉接头的影响]
[The effects of ethanol on neuromuscular junctions of adult toad].
作者信息
Yu J, Lü G, Xu J
机构信息
Department of Physiology, School of Basic Medical Sciences, WCUMS, Chengdu 610041, China.
出版信息
Hua Xi Yi Ke Da Xue Xue Bao. 2001 Jun;32(2):274-6.
OBJECTIVE
To investigate the effects of ethanol on the transmission at the neuromuscular junctions(NMJ) and the possible mechanism thereby.
METHODS
The effects of ethanol on the endplate potential (EPP) and miniature endplate potential(MEPP) of sciatic nerve-sartorious muscle preparations of 20 adult toads (Bufo bufo gargarizans) were studied in vitro by means of intracellular microelectrode recording.
RESULTS
Ethanol could cause the changes in EPP amplitude so as to influence the transmission at NMJ, and the effects apparently depended on the concentration of the ethanol. A proper concentration of ethanol could produce a significant increase in EPP amplitude and therefore facilitate the transmission at the NMJ. A proper concentration of ethanol also could produce a significant increase in MEPP frequency but had no influence on MEPP amplitude.
CONCLUSION
Ethanol can increase the quantal number of transmitters released from presynaptic part. That may be one of the reasons why ethanol can facilitate the transmission at the NMJ.
目的
研究乙醇对神经肌肉接头（NMJ）传递的影响及其可能机制。
方法
采用细胞内微电极记录技术，在体外研究乙醇对20只成年蟾蜍（中华大蟾蜍）坐骨神经-缝匠肌标本终板电位（EPP）和微小终板电位（MEPP）的影响。
结果
乙醇可引起EPP幅度改变，从而影响神经肌肉接头传递，其作用明显取决于乙醇浓度。适当浓度的乙醇可使EPP幅度显著增加，进而促进神经肌肉接头传递。适当浓度的乙醇还可使MEPP频率显著增加，但对MEPP幅度无影响。
结论
乙醇可增加突触前部分释放递质的量子数。这可能是乙醇促进神经肌肉接头传递的原因之一。
Zotero 插件